doc. Ing. Tibor Maliar, PhD.

MALIAR T.(25%), JEDINÁK A., KADRABOVÁ J., ŠTURDÍK E. Structural aspects of flavonoids as trypsin inhibitors, Eur. J. Med. Chem. 39: 241-248, 2004. (82 cit.). 

JEDINAK A., MALIAR T.(25%), GRANCAI D., NAGY M. Inhibition activities of natural products on serine proteases. Phytother. res. 20 (3): 214-217, 2006. (64 cit.).

JEDINAK A, MUCKOVA M, KOST'ALOVA D, MALIAR T., MASTEROVA I. Antiprotease and antimetastatic activity of ursolic acid isolated from Salvia officinalis. Z Naturforsch [C], 61(11-12): 777-782, 2006. (63 cit.).

JEDINAK A., MALIAR T(50%). Inhibitors of proteases as anticancer drugs. Neoplasma, 2(3):185-92, 2005. (48 cit.).

JTOSSII A., BONIN I., ANTCHEVA N., NORBEDO S., BENEDETTI F., MIERTUŠ S., NAIR C. A., MALIAR T.(10%), DAL BELLO F., PALU G., ROMEO D. Aspartic proteinase inhibitors: An integrated approach for the design and synthesis of diaminodiol based peptidomimetics, Eur. J. Biochem. 267: 1715-1722, 2000. (40 cit.).

Concurrent Analysis of Antioxidant and Pro-Oxidant Activities in Compounds from Plant Cell Cultures. [electronic] / Marcela Blažková, Ľubica Uváčková, Mária Maliarová, Jozef Sokol, Jana Viskupičová, Tibor Maliar, 2025. - Kategória do roku 2021 ADM. DOI DOI 10.3390/biotech14040091. In: BioTech. - ISSN 26736284 (online), Roč. 14, č. 4 (2025), s. 1-9 [online].

Koreň, J., Andrezál, M., Drahovská, H., Hubenáková, Z., Liptáková, A., Maliar, T.(8%): Next-Generation Sequencing of Carbapenem-Resistant Klebsiella pneumoniae Strains Isolated from Patients hospitalized in the University Hospital Facilities. Antibiotics, 11(11): 1538, 2022, (10 cit.).

Maliar, T.(20%); Maliarová, M.; Purdešová, A.; Jankech, T.; Gerhardtová, I.; Beňovič, P.; Dvořáček, V.; Jágr, M.; Viskupičová, J. The Adapted POM Analysis of Avenanthramides In Silico. Pharmaceuticals, , 16(5): 717, 2023, ( 15cit.).

Ürgeová, E.; Uváčková, Ľ.; Vaneková, M.; Maliar, T (20%). Antibacterial Potential of Microwave-Assisted Extraction Prepared Hydrolates from Different Salvia Species, Plants, 12(6): 1325, 2023 (12 cit.).

Maliar, T.; Maliarová, M., Blažková, M.; Kunštek, M.; Uváčková, Ľ.; Viskupičová, J.; Purdešová, A.; Beňovič, P. Simultaneously Determined Antioxidant and Pro-Oxidant Activity of Randomly Selected Plant Secondary Metabolites and Plant Extracts. Molecules, 28(19), 6890, 2023, (21 cit.).

MALIAR T., JEDINÁK A., KADRABOVÁ J., ŠTURDÍK E. Structural aspects of flavonoids as trypsin inhibitors, Eur. J. Med. Chem. 39: 241-248, 2004, 82 citácii.

1. Probing the binding mechanisms of alpha-tocopherol to trypsin and pepsin using isothermal titration calorimetry, spectroscopic, and molecular modeling methods. By: Li, Xiangrong; Ni, Tianjun. JOURNAL OF BIOLOGICAL PHYSICS Volume: 42 Issue: 3 Pages: 415-434 Published: JUN 2016.
2. Study on the interaction of -carotene and astaxanthin with trypsin and pepsin by spectroscopic techniques. By: Li, Xiangrong; Li, Peihong. LUMINESCENCE Volume: 31 Issue: 3 Pages: 782-792 Published: MAY 2016.
3. Probing the binding of procyanidin B3 to trypsin and pepsin: A multi-technique approach. By: Li, Xiangrong; Geng, Mingjiang. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Volume: 85 Pages: 168-178 Published: APR 2016.
4. Morin: A Promising Natural Drug. By: Caselli, Anna; Cirri, Paolo; Santi, Alice; et al. CURRENT MEDICINAL CHEMISTRY Volume: 23 Issue: 8 Pages: 774-791 Published: 2016.
5. Inhibitory effect of a quercetin-based soaking formulation and modified atmospheric packaging (MAP) on muscle degradation of Pacific white shrimp (Litopenaeus vannamei). By: Qian, Yun-Fang; Xie, Jing; Yang, Sheng-Ping; et al. LWT-FOOD SCIENCE AND TECHNOLOGY Volume: 63 Issue: 2 Pages: 1339-1346 Published: OCT 2015.

TOSSII A., BONIN I., ANTCHEVA N., NORBEDO S., BENEDETTI F., MIERTUŠ S., NAIR C. A., MALIAR T., DAL BELLO F., PALU G., ROMEO D. Aspartic proteinase inhibitors: An integrated approach for the design and synthesis of diaminodiol based peptidomimetics, Eur. J. Biochem. 267: 1715-1722, 2000, 40 cit.

1. Inhibitors of HIV-Protease from Computational Design. A History of Theory and Synthesis Still to be Fully Appreciated. By: Berti, Federico; Frecer, Vladimir; Miertus, Stanislav. CURRENT PHARMACEUTICAL DESIGN Volume: 20 Issue: 21 Pages: 3398-3411 Published: 2014.
2. Aspartic Peptidases of Human Pathogenic Trypanosomatids: Perspectives and Trends for Chemotherapy. By: Santos, L. O.; Garcia-Gomes, A. S.; Catanho, M.; et al. CURRENT MEDICINAL CHEMISTRY Volume: 20 Issue: 25 Pages: 3116-3133 Published: AUG 2013.
3. Design of Novel Dihydroxynaphthoic Acid Inhibitors of Plasmodium Falciparum Lactate Dehydrogenase. By: Megnassan, Eugene; Keita, Melalie; Bieri, Cecile; et al. MEDICINAL CHEMISTRY Volume: 8 Issue: 5 Pages: 970-984 Published: SEP 2012.
4. Design, Synthesis and Evaluation of Unique 2,4,5-triaryl Imidazole Derivatives as Novel Potent Aspartic Protease Inhibitors. By: Khan, Mohd Sajid; Akhtar, Salman; Siddiqui, S. A.; et al. MEDICINAL CHEMISTRY Volume: 8 Issue: 3 Pages: 428-435 Published: MAY 2012.
5. Synthesis and Biological Activity of Potent HIV-1 Protease Inhibitors Based on Phe-Pro Dihydroxyethylene Isosteres. Benedetti Fabio; Berti Federico; Budal Sara; et al. JOURNAL OF MEDICINAL CHEMISTRY Volume: 55 Issue: 8 Pages: 3900-391. 2012.

JEDINAK A., MALIAR T., GRANCAI D., NAGY M. Inhibition activities of natural products on serine proteases. Phytother. res. 20 (3): 214-217, 2006., 642 cit.

1. 1. Popular naturally ocurring antioxidants as potential anticoagulant drugs. By: Bijak, Michal; Saluk, Joanna; Szelenberger, Rafal; et al. CHEMICO-BIOLOGICAL INTERACTIONS Volume: 257 Pages: 35-45 Published: SEP 25 2016.
2. Enzyme Inhibitory and Molecular Docking Studies on Some Organic Molecules of Natural Occurrence. By: Abbasi, Muhammad Athar; Hussain, Ghulam; Aziz-ur-Rehman; et al. JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN Volume: 38 Issue: 1 Pages: 166-170 Published: FEB 2016.
3. Colloidal Aggregation and the in Vitro Activity of Traditional Chinese Medicines. By: Duan, Da; Doak, Allison K.; Nedyalkova, Lyudmila; et al. ACS CHEMICAL BIOLOGY Volume: 10 Issue: 4 Pages: 978-988 Published: APR 2015.
4. Evaluation of the Therapeutic Potential of Cefradine Metal Complexes. By: Danish, Muhammad; Raza, Muhammad A.; Sharif, Amina; et al. LATIN AMERICAN JOURNAL OF PHARMACY Volume: 34 Issue: 6 Pages: 1167-1171 Published: 2015.
5. Radical Scavenging, Proteases Activities, and Phenolics Composition of Bark Extracts from 21 Medicinal Plants. By: Raza, Muhammad Asam; Shahwar, Durre; Khan, Tania. JOURNAL OF CHEMISTRY Article Number: 951840 Published: 2015.

JEDINAK A, MUCKOVA M, KOSTALOVA D, MALIAR T., MASTEROVA I. Antiprotease and antimetastatic activity of ursolic acid isolated from Salvia officinalis. Z Naturforsch [C], 61(11-12): 777-782, 2006, 63 cit.

1. Ursolic acid (UA): A metabolite with promising therapeutic potential. By: Kashyap, Dharambir; Tuli, Hardeep Singh; Sharma, Anil K. LIFE SCIENCES Volume: 146 Pages: 201-213 Published: FEB 1 2016.
2. Role of Isoprenoid Compounds on Angiogenic Regulation: Opportunities and Challenges. By: Guerra, Angela R.; Duarte, Iola F.; Duarte, Maria F. CURRENT MEDICINAL CHEMISTRY Volume: 23 Issue: 9 Pages: 911-928 Published: 2016.
3. Bioactive Triterpenic Acids: From Agroforestry Biomass Residues to Promising Therapeutic Tools. By: Domingues, Rui M. A.; Guerra, Angela R.; Duarte, M.; et al. MINI-REVIEWS IN ORGANIC CHEMISTRY Volume: 11 Issue: 3 Pages: 382-399 Published: 2014.
4. Chemotype Diversity of Indigenous Dalmatian Sage (Salvia officinalis L.) Populations in Montenegro. By: Stesevic, Danijela; Ristic, Mihailo; Nikolic, Vuko; et al. CHEMISTRY & BIODIVERSITY Volume: 11 Issue: 1 Pages: 101-114 Published: JAN 2014.
5. Research progress of ursolic acid's anti-tumor actions. By: Zang Li-li; Wu Bao-ning; Lin Yuan; et al. CHINESE JOURNAL OF INTEGRATIVE MEDICINE Volume: 20 Issue: 1 Pages: 72-79 Published: JAN 2014.

JEDINAK A., MALIAR T. Inhibitors of proteases as anticancer drugs. Neoplasma, 2(3):185-92, 2005, 48 cit.

1. Characterization, biomedical and agricultural applications of protease inhibitors: A review. By: Shamsi, Tooba Naz; Parveen, Romana; Fatima, Sadaf. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Volume: 91 Pages: 1120-1133 Published: OCT 2016.
2. Cathepsin S: therapeutic, diagnostic, and prognostic potential. By: Wilkinson, Richard D. A.; Williams, Rich; Scott, Christopher J.; et al. BIOLOGICAL CHEMISTRY Volume: 396 Issue: 8 Pages: 867-882 Published: AUG 2015.
3. Acyl hydrazides and triazoles as novel inhibitors of mammalian cathepsin B and cathepsin H. By: Raghav, Neera; Singh, Mamta EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY Volume: 77 Pages: 231-242 Published: APR 2014.
4. Anti-proliferative and metastatic protease inhibitory activities of protoberberines: An in silico and in vitro approaches. By: Kumari, Seema; Kaladhar, D. S. V. G. K.; Solmon, K. Sandeep; et al. PROCESS BIOCHEMISTRY Volume: 48 Issue: 10 Pages: 1565-1571 Published: OCT 2013.
5. Silencing of Cathepsin B suppresses the proliferation and invasion of endometrial cancer. By: Bao, Wei; Fan, Qiong; Luo, Xin; et al. ONCOLOGY REPORTS Volume: 30 Issue: 2 Pages: 723-730 Published: AUG 2013

APVV-16-0173: Terapeutické alternatívy k liečbe rezistentných bakteriálnych infekcií. 2016-2021, 222 562,00 €, autor projektu a zástupca zodpovedného riešiteľa.

APVV-17-0113: Eliminácia toxicity avenínov pre zdravé, bezpečné i netradičné potravinové produkty. 2017-2021, 50 000,00 €, spoluautor projektu a vedúci dvoch etáp.

VEGA 01/0660/18: Výskum efektorov (inhibítorov a aktivátorov) karnozinázy (beta-alanyl-histidín dipeptidázy), s cieľom optimalizácie plazmatických a tkanivových hladín karnozínu. 2018-2020 20 000,00 €, autor projektu a zástupca zodpovedného riešiteľa.

APVV-20-0413: Fyzikálny „processing“ biomasy ako zdroj bio-aktívnych látok s antivirálnym, antibakteriálnym a protizápalovým účinkom pre ďalšie aplikácie. 2020 – 2023, 240 496 €, autor a zodpovedný riešiteľ projektu.

APVV-24-0180: Deriváty aromatických alkaloidov s antibakteriálnym účinkom ako spoločný predmet elicitácie rastlín pestovaných in vitro a syntetického výskumu. 2025-2028, 298 850 €, autor a zodpovedný riešiteľ projektu.